In recent years, the demand for mass spectrometry (MS)-based approaches for structural characterization in quality control of oligonucleotide-based pharmaceuticals has increased increased significantly. Sense strand RNAs with >30 nucleotide building blocks and labile modifications such as N-acetylgalactosamine residues represent thereby a special challenge. We will present direct, robust and easy-to-use techniques to fully characterize the nucleotide sequence of highly modified single-stranded RNAs by top down tandem MS. This will include a case study for an N-acetylgalactosamine modified RNA sense strand. The approach can be applied on single strand level, as well as on siRNA duplex level in a single electrospray ionization MS (ESI-MS) experiment. Based on this technique, we also developed an efficient and highly sophisticated LC-MS/MS workflow for the characterization of product-related impurities in oligonucleotides such as methylation, and PS-PO and rC/rU substitution. This procedure allows us to reliably predict the modification sites in oligonucleotide impurities to support process development with important structural information.
Novel approaches in MS characterization of highly modified synthetic RNA
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Execution time: 0.0017 seconds
Get to know our Speaker
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| text_shadow_color | rgba(0,0,0,0.4) |
| disabled | off |
| locked | off |
| global_colors_info | {} |
Execution time: 0.0016 seconds
ACF
| ID | 236699 |
| key | field_62ebe412a9c49 |
| label | Speaker Name |
| name | speaker_repeater_0_speaker_name |
| prefix | acf |
| type | text |
| value | Giovanni Calderisi |
| menu_order | 1 |
| required | 0 |
| conditional_logic | 0 |
| parent | 236697 |
| wrapper | Array ( [width] => [class] => [id] => ) |
| _name | speaker_name |
| _valid | 1 |
| parent_repeater | field_62ebe38ba9c47 |
Module Settings
| custom_identifier | ACF Item |
| acf_name | field_62ebe412a9c49 |
| is_author_acf_field | off |
| post_object_acf_name | none |
| author_field_type | author_post |
| linked_user_acf_name | none |
| type_taxonomy_acf_name | none |
| acf_tag | p |
| show_label | off |
| label_seperator | : |
| visibility | on |
| empty_value_option | hide_module |
| use_icon | off |
| icon_color | #2d7abf |
| use_circle | off |
| circle_color | #2d7abf |
| use_circle_border | off |
| circle_border_color | #2d7abf |
| use_icon_font_size | off |
| icon_image_placement | left |
| image_mobile_stacking | initial |
| return_format | array |
| image_link_url | off |
| image_link_url_acf_name | none |
| checkbox_style | array |
| checkbox_radio_return | label |
| checkbox_radio_value_type | off |
| checkbox_radio_link | off |
| link_button | off |
| email_subject | none |
| email_body_after | none |
| add_css_class | off |
| add_css_loop_layout | off |
| add_css_class_selector | body |
| link_new_tab | off |
| link_name_acf | off |
| link_name_acf_name | none |
| url_link_icon | off |
| image_size | full |
| true_false_condition | off |
| true_false_condition_css_selector | .et_pb_button |
| true_false_text_true | True |
| true_false_text_false | False |
| is_audio | off |
| is_video | off |
| video_loop | on |
| video_autoplay | on |
| make_video_background | off |
| video_background_size | cover |
| is_oembed_video | off |
| defer_video | off |
| defer_video_icon | I||divi||400 |
| video_icon_font_size | off |
| pretify_text | off |
| pretify_seperator | , |
| number_decimal | . |
| show_value_if_zero | off |
| text_image | off |
| is_options_page | off |
| is_repeater_loop_layout | on |
| linked_post_style | custom |
| link_post_seperator | , |
| link_to_post_object | on |
| link_to_post_object_new_tab | off |
| loop_layout | none |
| columns | 4 |
| columns_tablet | 2 |
| columns_mobile | 1 |
| user_field_return | display_name |
| link_to_author_page | off |
| repeater_dyn_btn_acf | none |
| text_before_position | same_line |
| label_position | same_line |
| vertical_alignment | middle |
| admin_label | DM - Speaker Name |
| _builder_version | 4.18.0 |
| _module_preset | default |
| title_css_font_size | 14px |
| title_css_letter_spacing | 0px |
| title_css_line_height | 1em |
| acf_label_css_font_size | 14px |
| acf_label_css_letter_spacing | 0px |
| acf_label_css_line_height | 1em |
| label_css_font | |700||on||||| |
| label_css_text_color | #004080 |
| label_css_letter_spacing | 0px |
| text_before_css_font_size | 14px |
| text_before_css_letter_spacing | 0px |
| text_before_css_line_height | 1em |
| seperator_font_size | 14px |
| seperator_letter_spacing | 0px |
| seperator_line_height | 1em |
| relational_field_item_font_size | 14px |
| relational_field_item_letter_spacing | 0px |
| relational_field_item_line_height | 1em |
| background_enable_color | on |
| use_background_color_gradient | off |
| background_color_gradient_repeat | off |
| background_color_gradient_type | linear |
| background_color_gradient_direction | 180deg |
| background_color_gradient_direction_radial | center |
| background_color_gradient_stops | #2b87da 0%|#29c4a9 100% |
| background_color_gradient_unit | % |
| background_color_gradient_overlays_image | off |
| background_color_gradient_start | #2b87da |
| background_color_gradient_start_position | 0% |
| background_color_gradient_end | #29c4a9 |
| background_color_gradient_end_position | 100% |
| background_enable_image | on |
| parallax | off |
| parallax_method | on |
| background_size | cover |
| background_image_width | auto |
| background_image_height | auto |
| background_position | center |
| background_horizontal_offset | 0 |
| background_vertical_offset | 0 |
| background_repeat | no-repeat |
| background_blend | normal |
| background_enable_video_mp4 | on |
| background_enable_video_webm | on |
| allow_player_pause | off |
| background_video_pause_outside_viewport | on |
| background_enable_pattern_style | off |
| background_pattern_style | polka-dots |
| background_pattern_color | rgba(0,0,0,0.2) |
| background_pattern_size | initial |
| background_pattern_width | auto |
| background_pattern_height | auto |
| background_pattern_repeat_origin | top_left |
| background_pattern_horizontal_offset | 0 |
| background_pattern_vertical_offset | 0 |
| background_pattern_repeat | repeat |
| background_pattern_blend_mode | normal |
| background_enable_mask_style | off |
| background_mask_style | layer-blob |
| background_mask_color | #ffffff |
| background_mask_aspect_ratio | landscape |
| background_mask_size | stretch |
| background_mask_width | auto |
| background_mask_height | auto |
| background_mask_position | center |
| background_mask_horizontal_offset | 0 |
| background_mask_vertical_offset | 0 |
| background_mask_blend_mode | normal |
| custom_button | off |
| button_text_size | 14 |
| button_bg_use_color_gradient | off |
| button_bg_color_gradient_repeat | off |
| button_bg_color_gradient_type | linear |
| button_bg_color_gradient_direction | 180deg |
| button_bg_color_gradient_direction_radial | center |
| button_bg_color_gradient_stops | #2b87da 0%|#29c4a9 100% |
| button_bg_color_gradient_unit | % |
| button_bg_color_gradient_overlays_image | off |
| button_bg_color_gradient_start | #2b87da |
| button_bg_color_gradient_start_position | 0% |
| button_bg_color_gradient_end | #29c4a9 |
| button_bg_color_gradient_end_position | 100% |
| button_bg_enable_image | on |
| button_bg_parallax | off |
| button_bg_parallax_method | on |
| button_bg_size | cover |
| button_bg_image_width | auto |
| button_bg_image_height | auto |
| button_bg_position | center |
| button_bg_horizontal_offset | 0 |
| button_bg_vertical_offset | 0 |
| button_bg_repeat | no-repeat |
| button_bg_blend | normal |
| button_bg_enable_video_mp4 | on |
| button_bg_enable_video_webm | on |
| button_bg_allow_player_pause | off |
| button_bg_video_pause_outside_viewport | on |
| button_use_icon | on |
| button_icon_placement | right |
| button_on_hover | on |
| positioning | none |
| position_origin_a | top_left |
| position_origin_f | top_left |
| position_origin_r | top_left |
| width | auto |
| max_width | none |
| min_height | auto |
| height | auto |
| max_height | none |
| custom_margin | ||0px||false|false |
| custom_padding | ||0px||false|false |
| filter_hue_rotate | 0deg |
| filter_saturate | 100% |
| filter_brightness | 100% |
| filter_contrast | 100% |
| filter_invert | 0% |
| filter_sepia | 0% |
| filter_opacity | 100% |
| filter_blur | 0px |
| mix_blend_mode | normal |
| animation_style | none |
| animation_direction | center |
| animation_duration | 1000ms |
| animation_delay | 0ms |
| animation_intensity_slide | 50% |
| animation_intensity_zoom | 50% |
| animation_intensity_flip | 50% |
| animation_intensity_fold | 50% |
| animation_intensity_roll | 50% |
| animation_starting_opacity | 0% |
| animation_speed_curve | ease-in-out |
| animation_repeat | once |
| hover_transition_duration | 300ms |
| hover_transition_delay | 0ms |
| hover_transition_speed_curve | ease |
| link_option_url_new_window | off |
| sticky_position | none |
| sticky_offset_top | 0px |
| sticky_offset_bottom | 0px |
| sticky_limit_top | none |
| sticky_limit_bottom | none |
| sticky_offset_surrounding | on |
| sticky_transition | on |
| motion_trigger_start | middle |
| hover_enabled | 0 |
| title_css_text_shadow_style | none |
| title_css_text_shadow_horizontal_length | 0em |
| title_css_text_shadow_vertical_length | 0em |
| title_css_text_shadow_blur_strength | 0em |
| title_css_text_shadow_color | rgba(0,0,0,0.4) |
| acf_label_css_text_shadow_style | none |
| acf_label_css_text_shadow_horizontal_length | 0em |
| acf_label_css_text_shadow_vertical_length | 0em |
| acf_label_css_text_shadow_blur_strength | 0em |
| acf_label_css_text_shadow_color | rgba(0,0,0,0.4) |
| label_css_text_shadow_style | none |
| label_css_text_shadow_horizontal_length | 0em |
| label_css_text_shadow_vertical_length | 0em |
| label_css_text_shadow_blur_strength | 0em |
| label_css_text_shadow_color | rgba(0,0,0,0.4) |
| text_before_css_text_shadow_style | none |
| text_before_css_text_shadow_horizontal_length | 0em |
| text_before_css_text_shadow_vertical_length | 0em |
| text_before_css_text_shadow_blur_strength | 0em |
| text_before_css_text_shadow_color | rgba(0,0,0,0.4) |
| seperator_text_shadow_style | none |
| seperator_text_shadow_horizontal_length | 0em |
| seperator_text_shadow_vertical_length | 0em |
| seperator_text_shadow_blur_strength | 0em |
| seperator_text_shadow_color | rgba(0,0,0,0.4) |
| relational_field_item_text_shadow_style | none |
| relational_field_item_text_shadow_horizontal_length | 0em |
| relational_field_item_text_shadow_vertical_length | 0em |
| relational_field_item_text_shadow_blur_strength | 0em |
| relational_field_item_text_shadow_color | rgba(0,0,0,0.4) |
| button_text_shadow_style | none |
| button_text_shadow_horizontal_length | 0em |
| button_text_shadow_vertical_length | 0em |
| button_text_shadow_blur_strength | 0em |
| button_text_shadow_color | rgba(0,0,0,0.4) |
| box_shadow_style | none |
| box_shadow_color | rgba(0,0,0,0.3) |
| box_shadow_position | outer |
| box_shadow_style_button | none |
| box_shadow_color_button | rgba(0,0,0,0.3) |
| box_shadow_position_button | outer |
| text_shadow_style | none |
| text_shadow_horizontal_length | 0em |
| text_shadow_vertical_length | 0em |
| text_shadow_blur_strength | 0em |
| text_shadow_color | rgba(0,0,0,0.4) |
| disabled | off |
| locked | off |
| global_colors_info | {"gcid-26ed69e5-024e-4d79-af60-a0cd8f862966":["label_css_text_color"]} |
Giovanni Calderisi
Execution time: 0.0013 seconds
ACF
| ID | 236700 |
| key | field_62ebe420a9c4a |
| label | Speaker Title |
| name | speaker_repeater_0_speaker_title |
| prefix | acf |
| type | text |
| value | Project Chemist QC |
| menu_order | 2 |
| required | 0 |
| conditional_logic | 0 |
| parent | 236697 |
| wrapper | Array ( [width] => [class] => [id] => ) |
| _name | speaker_title |
| _valid | 1 |
| parent_repeater | field_62ebe38ba9c47 |
Module Settings
| custom_identifier | ACF Item |
| acf_name | field_62ebe420a9c4a |
| is_author_acf_field | off |
| post_object_acf_name | none |
| author_field_type | author_post |
| linked_user_acf_name | none |
| type_taxonomy_acf_name | none |
| acf_tag | p |
| show_label | off |
| label_seperator | : |
| visibility | on |
| empty_value_option | hide_module |
| use_icon | off |
| icon_color | #2d7abf |
| use_circle | off |
| circle_color | #2d7abf |
| use_circle_border | off |
| circle_border_color | #2d7abf |
| use_icon_font_size | off |
| icon_image_placement | left |
| image_mobile_stacking | initial |
| return_format | array |
| image_link_url | off |
| image_link_url_acf_name | none |
| checkbox_style | array |
| checkbox_radio_return | label |
| checkbox_radio_value_type | off |
| checkbox_radio_link | off |
| link_button | off |
| email_subject | none |
| email_body_after | none |
| add_css_class | off |
| add_css_loop_layout | off |
| add_css_class_selector | body |
| link_new_tab | off |
| link_name_acf | off |
| link_name_acf_name | none |
| url_link_icon | off |
| image_size | full |
| true_false_condition | off |
| true_false_condition_css_selector | .et_pb_button |
| true_false_text_true | True |
| true_false_text_false | False |
| is_audio | off |
| is_video | off |
| video_loop | on |
| video_autoplay | on |
| make_video_background | off |
| video_background_size | cover |
| is_oembed_video | off |
| defer_video | off |
| defer_video_icon | I||divi||400 |
| video_icon_font_size | off |
| pretify_text | off |
| pretify_seperator | , |
| number_decimal | . |
| show_value_if_zero | off |
| text_image | off |
| is_options_page | off |
| is_repeater_loop_layout | on |
| linked_post_style | custom |
| link_post_seperator | , |
| link_to_post_object | on |
| link_to_post_object_new_tab | off |
| loop_layout | none |
| columns | 4 |
| columns_tablet | 2 |
| columns_mobile | 1 |
| user_field_return | display_name |
| link_to_author_page | off |
| repeater_dyn_btn_acf | none |
| text_before_position | same_line |
| label_position | same_line |
| vertical_alignment | middle |
| admin_label | DM - Speaker Title |
| _builder_version | 4.18.0 |
| _module_preset | default |
| title_css_font_size | 14px |
| title_css_letter_spacing | 0px |
| title_css_line_height | 1em |
| acf_label_css_font_size | 14px |
| acf_label_css_letter_spacing | 0px |
| acf_label_css_line_height | 1em |
| label_css_font | |700||||||| |
| label_css_text_color | #2d7abf |
| label_css_letter_spacing | 0px |
| text_before_css_font_size | 14px |
| text_before_css_letter_spacing | 0px |
| text_before_css_line_height | 1em |
| seperator_font_size | 14px |
| seperator_letter_spacing | 0px |
| seperator_line_height | 1em |
| relational_field_item_font_size | 14px |
| relational_field_item_letter_spacing | 0px |
| relational_field_item_line_height | 1em |
| background_enable_color | on |
| use_background_color_gradient | off |
| background_color_gradient_repeat | off |
| background_color_gradient_type | linear |
| background_color_gradient_direction | 180deg |
| background_color_gradient_direction_radial | center |
| background_color_gradient_stops | #2b87da 0%|#29c4a9 100% |
| background_color_gradient_unit | % |
| background_color_gradient_overlays_image | off |
| background_color_gradient_start | #2b87da |
| background_color_gradient_start_position | 0% |
| background_color_gradient_end | #29c4a9 |
| background_color_gradient_end_position | 100% |
| background_enable_image | on |
| parallax | off |
| parallax_method | on |
| background_size | cover |
| background_image_width | auto |
| background_image_height | auto |
| background_position | center |
| background_horizontal_offset | 0 |
| background_vertical_offset | 0 |
| background_repeat | no-repeat |
| background_blend | normal |
| background_enable_video_mp4 | on |
| background_enable_video_webm | on |
| allow_player_pause | off |
| background_video_pause_outside_viewport | on |
| background_enable_pattern_style | off |
| background_pattern_style | polka-dots |
| background_pattern_color | rgba(0,0,0,0.2) |
| background_pattern_size | initial |
| background_pattern_width | auto |
| background_pattern_height | auto |
| background_pattern_repeat_origin | top_left |
| background_pattern_horizontal_offset | 0 |
| background_pattern_vertical_offset | 0 |
| background_pattern_repeat | repeat |
| background_pattern_blend_mode | normal |
| background_enable_mask_style | off |
| background_mask_style | layer-blob |
| background_mask_color | #ffffff |
| background_mask_aspect_ratio | landscape |
| background_mask_size | stretch |
| background_mask_width | auto |
| background_mask_height | auto |
| background_mask_position | center |
| background_mask_horizontal_offset | 0 |
| background_mask_vertical_offset | 0 |
| background_mask_blend_mode | normal |
| custom_button | off |
| button_text_size | 14 |
| button_bg_use_color_gradient | off |
| button_bg_color_gradient_repeat | off |
| button_bg_color_gradient_type | linear |
| button_bg_color_gradient_direction | 180deg |
| button_bg_color_gradient_direction_radial | center |
| button_bg_color_gradient_stops | #2b87da 0%|#29c4a9 100% |
| button_bg_color_gradient_unit | % |
| button_bg_color_gradient_overlays_image | off |
| button_bg_color_gradient_start | #2b87da |
| button_bg_color_gradient_start_position | 0% |
| button_bg_color_gradient_end | #29c4a9 |
| button_bg_color_gradient_end_position | 100% |
| button_bg_enable_image | on |
| button_bg_parallax | off |
| button_bg_parallax_method | on |
| button_bg_size | cover |
| button_bg_image_width | auto |
| button_bg_image_height | auto |
| button_bg_position | center |
| button_bg_horizontal_offset | 0 |
| button_bg_vertical_offset | 0 |
| button_bg_repeat | no-repeat |
| button_bg_blend | normal |
| button_bg_enable_video_mp4 | on |
| button_bg_enable_video_webm | on |
| button_bg_allow_player_pause | off |
| button_bg_video_pause_outside_viewport | on |
| button_use_icon | on |
| button_icon_placement | right |
| button_on_hover | on |
| positioning | none |
| position_origin_a | top_left |
| position_origin_f | top_left |
| position_origin_r | top_left |
| width | auto |
| max_width | none |
| min_height | auto |
| height | auto |
| max_height | none |
| custom_margin | 0px||||false|false |
| custom_padding | 0px||||false|false |
| filter_hue_rotate | 0deg |
| filter_saturate | 100% |
| filter_brightness | 100% |
| filter_contrast | 100% |
| filter_invert | 0% |
| filter_sepia | 0% |
| filter_opacity | 100% |
| filter_blur | 0px |
| mix_blend_mode | normal |
| animation_style | none |
| animation_direction | center |
| animation_duration | 1000ms |
| animation_delay | 0ms |
| animation_intensity_slide | 50% |
| animation_intensity_zoom | 50% |
| animation_intensity_flip | 50% |
| animation_intensity_fold | 50% |
| animation_intensity_roll | 50% |
| animation_starting_opacity | 0% |
| animation_speed_curve | ease-in-out |
| animation_repeat | once |
| hover_transition_duration | 300ms |
| hover_transition_delay | 0ms |
| hover_transition_speed_curve | ease |
| link_option_url_new_window | off |
| sticky_position | none |
| sticky_offset_top | 0px |
| sticky_offset_bottom | 0px |
| sticky_limit_top | none |
| sticky_limit_bottom | none |
| sticky_offset_surrounding | on |
| sticky_transition | on |
| motion_trigger_start | middle |
| hover_enabled | 0 |
| title_css_text_shadow_style | none |
| title_css_text_shadow_horizontal_length | 0em |
| title_css_text_shadow_vertical_length | 0em |
| title_css_text_shadow_blur_strength | 0em |
| title_css_text_shadow_color | rgba(0,0,0,0.4) |
| acf_label_css_text_shadow_style | none |
| acf_label_css_text_shadow_horizontal_length | 0em |
| acf_label_css_text_shadow_vertical_length | 0em |
| acf_label_css_text_shadow_blur_strength | 0em |
| acf_label_css_text_shadow_color | rgba(0,0,0,0.4) |
| label_css_text_shadow_style | none |
| label_css_text_shadow_horizontal_length | 0em |
| label_css_text_shadow_vertical_length | 0em |
| label_css_text_shadow_blur_strength | 0em |
| label_css_text_shadow_color | rgba(0,0,0,0.4) |
| text_before_css_text_shadow_style | none |
| text_before_css_text_shadow_horizontal_length | 0em |
| text_before_css_text_shadow_vertical_length | 0em |
| text_before_css_text_shadow_blur_strength | 0em |
| text_before_css_text_shadow_color | rgba(0,0,0,0.4) |
| seperator_text_shadow_style | none |
| seperator_text_shadow_horizontal_length | 0em |
| seperator_text_shadow_vertical_length | 0em |
| seperator_text_shadow_blur_strength | 0em |
| seperator_text_shadow_color | rgba(0,0,0,0.4) |
| relational_field_item_text_shadow_style | none |
| relational_field_item_text_shadow_horizontal_length | 0em |
| relational_field_item_text_shadow_vertical_length | 0em |
| relational_field_item_text_shadow_blur_strength | 0em |
| relational_field_item_text_shadow_color | rgba(0,0,0,0.4) |
| button_text_shadow_style | none |
| button_text_shadow_horizontal_length | 0em |
| button_text_shadow_vertical_length | 0em |
| button_text_shadow_blur_strength | 0em |
| button_text_shadow_color | rgba(0,0,0,0.4) |
| box_shadow_style | none |
| box_shadow_color | rgba(0,0,0,0.3) |
| box_shadow_position | outer |
| box_shadow_style_button | none |
| box_shadow_color_button | rgba(0,0,0,0.3) |
| box_shadow_position_button | outer |
| text_shadow_style | none |
| text_shadow_horizontal_length | 0em |
| text_shadow_vertical_length | 0em |
| text_shadow_blur_strength | 0em |
| text_shadow_color | rgba(0,0,0,0.4) |
| disabled | off |
| locked | off |
| global_colors_info | {"gcid-f71e32a6-6d24-4beb-adc3-f38b1f4074ed":["label_css_text_color"]} |
Project Chemist QC
Execution time: 0.0014 seconds
ACF
| ID | 237387 |
| key | field_633152eb435af |
| label | Speaker Bio |
| name | speaker_repeater_0_speaker_bio |
| prefix | acf |
| type | wysiwyg |
| value | <p>Giovanni joined Bachem in Bubendorf (Switzerland) in September 2020 as an expert for mass spectrometry (MS) of oligonucleotides. In his position as a project chemist he is responsible for establishing routine workflows the for characterization of oligonucleotides and peptides by ultra-high resolution MS. Giovanni received his Ph.D. in chemistry with a focus on biomolecular MS at the University of Innsbruck, Austria.</p> |
| menu_order | 3 |
| required | 0 |
| conditional_logic | 0 |
| parent | 236697 |
| wrapper | Array ( [width] => [class] => [id] => ) |
| delay | 0 |
| tabs | all |
| toolbar | basic |
| media_upload | 0 |
| _name | speaker_bio |
| _valid | 1 |
| parent_repeater | field_62ebe38ba9c47 |
Module Settings
| custom_identifier | ACF Item |
| acf_name | field_633152eb435af |
| is_author_acf_field | off |
| post_object_acf_name | none |
| author_field_type | author_post |
| linked_user_acf_name | none |
| type_taxonomy_acf_name | none |
| acf_tag | p |
| show_label | off |
| label_seperator | : |
| visibility | on |
| empty_value_option | hide_module |
| use_icon | off |
| icon_color | #2d7abf |
| use_circle | off |
| circle_color | #2d7abf |
| use_circle_border | off |
| circle_border_color | #2d7abf |
| use_icon_font_size | off |
| icon_image_placement | left |
| image_mobile_stacking | initial |
| return_format | array |
| image_link_url | off |
| image_link_url_acf_name | none |
| checkbox_style | array |
| checkbox_radio_return | label |
| checkbox_radio_value_type | off |
| checkbox_radio_link | off |
| link_button | off |
| email_subject | none |
| email_body_after | none |
| add_css_class | off |
| add_css_loop_layout | off |
| add_css_class_selector | body |
| link_new_tab | off |
| link_name_acf | off |
| link_name_acf_name | none |
| url_link_icon | off |
| image_size | full |
| true_false_condition | off |
| true_false_condition_css_selector | .et_pb_button |
| true_false_text_true | True |
| true_false_text_false | False |
| is_audio | off |
| is_video | off |
| video_loop | on |
| video_autoplay | on |
| make_video_background | off |
| video_background_size | cover |
| is_oembed_video | off |
| defer_video | off |
| defer_video_icon | I||divi||400 |
| video_icon_font_size | off |
| pretify_text | off |
| pretify_seperator | , |
| number_decimal | . |
| show_value_if_zero | off |
| text_image | off |
| is_options_page | off |
| is_repeater_loop_layout | on |
| linked_post_style | custom |
| link_post_seperator | , |
| link_to_post_object | on |
| link_to_post_object_new_tab | off |
| loop_layout | none |
| columns | 4 |
| columns_tablet | 2 |
| columns_mobile | 1 |
| user_field_return | display_name |
| link_to_author_page | off |
| repeater_dyn_btn_acf | none |
| text_before_position | same_line |
| label_position | same_line |
| vertical_alignment | middle |
| admin_label | DM - Speaker Bio |
| _builder_version | 4.18.0 |
| _module_preset | default |
| title_css_font_size | 14px |
| title_css_letter_spacing | 0px |
| title_css_line_height | 1em |
| acf_label_css_font_size | 14px |
| acf_label_css_letter_spacing | 0px |
| acf_label_css_line_height | 1em |
| label_css_font | |||||||| |
| label_css_letter_spacing | 0px |
| text_before_css_font_size | 14px |
| text_before_css_letter_spacing | 0px |
| text_before_css_line_height | 1em |
| seperator_font_size | 14px |
| seperator_letter_spacing | 0px |
| seperator_line_height | 1em |
| relational_field_item_font_size | 14px |
| relational_field_item_letter_spacing | 0px |
| relational_field_item_line_height | 1em |
| background_enable_color | on |
| use_background_color_gradient | off |
| background_color_gradient_repeat | off |
| background_color_gradient_type | linear |
| background_color_gradient_direction | 180deg |
| background_color_gradient_direction_radial | center |
| background_color_gradient_stops | #2b87da 0%|#29c4a9 100% |
| background_color_gradient_unit | % |
| background_color_gradient_overlays_image | off |
| background_color_gradient_start | #2b87da |
| background_color_gradient_start_position | 0% |
| background_color_gradient_end | #29c4a9 |
| background_color_gradient_end_position | 100% |
| background_enable_image | on |
| parallax | off |
| parallax_method | on |
| background_size | cover |
| background_image_width | auto |
| background_image_height | auto |
| background_position | center |
| background_horizontal_offset | 0 |
| background_vertical_offset | 0 |
| background_repeat | no-repeat |
| background_blend | normal |
| background_enable_video_mp4 | on |
| background_enable_video_webm | on |
| allow_player_pause | off |
| background_video_pause_outside_viewport | on |
| background_enable_pattern_style | off |
| background_pattern_style | polka-dots |
| background_pattern_color | rgba(0,0,0,0.2) |
| background_pattern_size | initial |
| background_pattern_width | auto |
| background_pattern_height | auto |
| background_pattern_repeat_origin | top_left |
| background_pattern_horizontal_offset | 0 |
| background_pattern_vertical_offset | 0 |
| background_pattern_repeat | repeat |
| background_pattern_blend_mode | normal |
| background_enable_mask_style | off |
| background_mask_style | layer-blob |
| background_mask_color | #ffffff |
| background_mask_aspect_ratio | landscape |
| background_mask_size | stretch |
| background_mask_width | auto |
| background_mask_height | auto |
| background_mask_position | center |
| background_mask_horizontal_offset | 0 |
| background_mask_vertical_offset | 0 |
| background_mask_blend_mode | normal |
| custom_button | off |
| button_text_size | 14 |
| button_bg_use_color_gradient | off |
| button_bg_color_gradient_repeat | off |
| button_bg_color_gradient_type | linear |
| button_bg_color_gradient_direction | 180deg |
| button_bg_color_gradient_direction_radial | center |
| button_bg_color_gradient_stops | #2b87da 0%|#29c4a9 100% |
| button_bg_color_gradient_unit | % |
| button_bg_color_gradient_overlays_image | off |
| button_bg_color_gradient_start | #2b87da |
| button_bg_color_gradient_start_position | 0% |
| button_bg_color_gradient_end | #29c4a9 |
| button_bg_color_gradient_end_position | 100% |
| button_bg_enable_image | on |
| button_bg_parallax | off |
| button_bg_parallax_method | on |
| button_bg_size | cover |
| button_bg_image_width | auto |
| button_bg_image_height | auto |
| button_bg_position | center |
| button_bg_horizontal_offset | 0 |
| button_bg_vertical_offset | 0 |
| button_bg_repeat | no-repeat |
| button_bg_blend | normal |
| button_bg_enable_video_mp4 | on |
| button_bg_enable_video_webm | on |
| button_bg_allow_player_pause | off |
| button_bg_video_pause_outside_viewport | on |
| button_use_icon | on |
| button_icon_placement | right |
| button_on_hover | on |
| positioning | none |
| position_origin_a | top_left |
| position_origin_f | top_left |
| position_origin_r | top_left |
| width | auto |
| max_width | none |
| min_height | auto |
| height | auto |
| max_height | none |
| custom_margin | 0px||||false|false |
| custom_padding | 0px||||false|false |
| filter_hue_rotate | 0deg |
| filter_saturate | 100% |
| filter_brightness | 100% |
| filter_contrast | 100% |
| filter_invert | 0% |
| filter_sepia | 0% |
| filter_opacity | 100% |
| filter_blur | 0px |
| mix_blend_mode | normal |
| animation_style | none |
| animation_direction | center |
| animation_duration | 1000ms |
| animation_delay | 0ms |
| animation_intensity_slide | 50% |
| animation_intensity_zoom | 50% |
| animation_intensity_flip | 50% |
| animation_intensity_fold | 50% |
| animation_intensity_roll | 50% |
| animation_starting_opacity | 0% |
| animation_speed_curve | ease-in-out |
| animation_repeat | once |
| hover_transition_duration | 300ms |
| hover_transition_delay | 0ms |
| hover_transition_speed_curve | ease |
| link_option_url_new_window | off |
| sticky_position | none |
| sticky_offset_top | 0px |
| sticky_offset_bottom | 0px |
| sticky_limit_top | none |
| sticky_limit_bottom | none |
| sticky_offset_surrounding | on |
| sticky_transition | on |
| motion_trigger_start | middle |
| hover_enabled | 0 |
| title_css_text_shadow_style | none |
| title_css_text_shadow_horizontal_length | 0em |
| title_css_text_shadow_vertical_length | 0em |
| title_css_text_shadow_blur_strength | 0em |
| title_css_text_shadow_color | rgba(0,0,0,0.4) |
| acf_label_css_text_shadow_style | none |
| acf_label_css_text_shadow_horizontal_length | 0em |
| acf_label_css_text_shadow_vertical_length | 0em |
| acf_label_css_text_shadow_blur_strength | 0em |
| acf_label_css_text_shadow_color | rgba(0,0,0,0.4) |
| label_css_text_shadow_style | none |
| label_css_text_shadow_horizontal_length | 0em |
| label_css_text_shadow_vertical_length | 0em |
| label_css_text_shadow_blur_strength | 0em |
| label_css_text_shadow_color | rgba(0,0,0,0.4) |
| text_before_css_text_shadow_style | none |
| text_before_css_text_shadow_horizontal_length | 0em |
| text_before_css_text_shadow_vertical_length | 0em |
| text_before_css_text_shadow_blur_strength | 0em |
| text_before_css_text_shadow_color | rgba(0,0,0,0.4) |
| seperator_text_shadow_style | none |
| seperator_text_shadow_horizontal_length | 0em |
| seperator_text_shadow_vertical_length | 0em |
| seperator_text_shadow_blur_strength | 0em |
| seperator_text_shadow_color | rgba(0,0,0,0.4) |
| relational_field_item_text_shadow_style | none |
| relational_field_item_text_shadow_horizontal_length | 0em |
| relational_field_item_text_shadow_vertical_length | 0em |
| relational_field_item_text_shadow_blur_strength | 0em |
| relational_field_item_text_shadow_color | rgba(0,0,0,0.4) |
| button_text_shadow_style | none |
| button_text_shadow_horizontal_length | 0em |
| button_text_shadow_vertical_length | 0em |
| button_text_shadow_blur_strength | 0em |
| button_text_shadow_color | rgba(0,0,0,0.4) |
| box_shadow_style | none |
| box_shadow_color | rgba(0,0,0,0.3) |
| box_shadow_position | outer |
| box_shadow_style_button | none |
| box_shadow_color_button | rgba(0,0,0,0.3) |
| box_shadow_position_button | outer |
| text_shadow_style | none |
| text_shadow_horizontal_length | 0em |
| text_shadow_vertical_length | 0em |
| text_shadow_blur_strength | 0em |
| text_shadow_color | rgba(0,0,0,0.4) |
| disabled | off |
| locked | off |
| global_colors_info | {} |
Giovanni joined Bachem in Bubendorf (Switzerland) in September 2020 as an expert for mass spectrometry (MS) of oligonucleotides. In his position as a project chemist he is responsible for establishing routine workflows the for characterization of oligonucleotides and peptides by ultra-high resolution MS. Giovanni received his Ph.D. in chemistry with a focus on biomolecular MS at the University of Innsbruck, Austria.
Execution time: 0.0022 seconds
Execution time: 0.0004 seconds
Webinars
A turn in peptide purification – Peptide Easy Clean (PEC)
Avoiding epimerization in peptide synthesis
Bachem capabilities to address the new FDA guideline for synthetic peptides
Bachem Group CSR Strategy 2022 – 2026
Beyond automation: Towards a smart factory
CEPS for protein synthesis – selected examples of complex proteins
CEPS Technology – Peptiligase Selection & Engineering
Chemo Enzymatic Ligation
CMC Development of Peptides, A Case Study
Continuous Chromatography of Peptides
Corporate Social Responsibility webinar
Cost-efficient and green manufacturing of peptides thanks to Molecular Hiving technology
Do it Right, by not Doing it Yourself – the Value of a Good CDMO Partner
From Idea to Application – Enabling Better Peptide Drugs. A start-up story about Belyntic
High-resolution mass spectrometry of oligonucleotides – characterization made easy
Implementation of industry 4.0 concepts for the manufacturing of “Tides”
ISO 13485: The Perfect Fit for Peptide-Based In Vitro Diagnostics
Large-scale TIDES purification with MCSGP under GMP
Learn about methods for making long and complex peptides
Microspheres and Nanoparticles for Peptide Delivery