Scalable oligonucleotide manufacture with stirred-bed technology

Based on decades of experience in applying stirred-bed reactors for making peptides, we investigated whether these could be used for the manufacturing of oligonucleotides as well. Join our webinar on scalable oligonucleotide manufacturing with stirred-bed technology (SBT) to learn how we can reach commercial oligonucleotides API production in metric ton range with unbeaten process mass intensity. You will get insights into case studies, our SBT capacities for R&D to large scale production projects, and typical CMC activities for scale-up. Finally, we will share the distinct advantages stirred-bed solid-phase oligonucleotide synthesis (SPOS) has over classical fixed-bed SPOS.

 

Get to know our speakers

DANIEL SAMSON, PH.D

Vice President, Head Oligonucleotides

Daniel brings 15 years of industry experience to the team, with an emphasis on TIDES process R&D, manufacturing and CMC development. He leads Bachem’s oligonucleotide unit including innovation projects, R&D and manufacturing activities. Daniel holds a PhD in organic chemistry from the University of Konstanz, and an MBA from the International Institute for Management Development (IMD), Lausanne. In previous stages of his career he was a lab head for process optimization, technology transfer, Quality by Design, and scale-up of synthetic peptide manufacturing procedures. From 2012, Daniel was a Vice President API Manufacturing and had full responsibility for all large-scale solid phase peptide and oligonucleotide syntheses, downstream operations, and CMC activities within Bachem AG.

CHRIS MCGEE, PH.D.

Vice President, Head Global Business Development

Chris leads the Global Business Development department at Bachem. Previously, he was Senior Director of Business Development (BD) for Bachem Americas. As Senior Director of BD, he was at the forefront of communications related to the development and manufacturing of new peptide and oligonucleotide-based chemical entities with his team of peptide experts in the field. Chris has nearly a decade of experience at Bachem and previously earned a Ph.D. in organic chemistry from the University of California, Irvine.

White Paper: Improving Oligonucleotide Manufacture with stirred-bed technology

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