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Efficient Large-scale SiRNA Manufacturing: Enzymatic Ligation of Short RNA Fragments

Efficient Large-scale SiRNA Manufacturing: Enzymatic Ligation of Short RNA Fragments

Nov 5, 2025 | Generic API, Innovation, Oligos NCE, Services & Capabilities, Sustainability

Linear synthesis by continuous-flow SPOS is the current state-of-the-art technology to manufacture oligonucleotide APIs. A very promising alternative, especially to manufacture large quantities, is the enzymatic ligation of short oligonucleotide fragments. This...
How to assess and reduce Nitrosamine Contamination Risks in Peptide APIs

How to assess and reduce Nitrosamine Contamination Risks in Peptide APIs

Sep 24, 2024 | Generic API, Peptides NCE, Research & Specialties, Sustainability

Recent years have seen drug recalls based on nitrosamine drug substance related impurities (NDSRIs), with medical agencies advising API manufacturers to implement risk assessment and mitigation strategies to meet safety and regulatory requirements. CDMOs often serve...
Going Large-scale with Manufacturing of Oligonucleotides

Going Large-scale with Manufacturing of Oligonucleotides

May 15, 2024 | Innovation, Oligos NCE, Sustainability

The growing number of oligonucleotide-based APIs is accompanied by an increasing need for efficient routes for their large-scale manufacturing. It is therefore essential to develop more efficient, more sustainable, and highly scalable manufacturing techniques. The...
More than white Powder and Reports

More than white Powder and Reports

Jan 31, 2024 | Generic API, Oligos NCE, Peptides NCE, Research & Specialties, Services & Capabilities, Sustainability

Bachem is a peptide and oligonucleotide manufacturer undergoing a steep growth curve together with our partners in pharmaceutical industry. Customer-related project management (PM) is a key contributor to this growth. Join this webinar to get insights about our PM...
Large-scale TIDES purification with MCSGP under GMP

Large-scale TIDES purification with MCSGP under GMP

Dec 5, 2023 | Generic API, Innovation, Oligos NCE, Peptides NCE, Services & Capabilities, Sustainability

Throughout industry the trend goes from producing batches to continuous production. Due to the increasing need for efficient methods to produce peptides and oligonucleotides on a large scale, Bachem was the first TIDES manufacturer to introduce Multicolumn...
Tag-assisted One-Pot Liquid-phase Oligonucleotide Synthesis

Tag-assisted One-Pot Liquid-phase Oligonucleotide Synthesis

Nov 15, 2023 | Innovation, Oligos NCE, Sustainability

Learn more on Bachem’s new one-pot process of synthesizing oligonucleotides in liquid-phase utilizing new pseudo-solid-phase protecting groups (tags). This process holds promise to be more efficient and environmentally friendly than current commercial processes....
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