Human β-Defensin 2 HBD2
Disulfide Pattern CysI-CysV, CysII-CysIV, CysIII-CysVI
θ-defensins are cyclic peptides of 18 amino acids. They are derived from two nonapeptide precursors, which are fused in a head-to-tail fashion. θ-defensins are characterized by three disulfide bonds in a CysI–CysVI, CysII–CysV, CysIII–CysIV arrangement (Fig 2). They are named like this because of their structural similarity to the Greek letter theta. The first θ-defensin was discovered in rhesus macaque (Macacca mulata) leukocytes and later on found in other non-human primates.
Figure 2 Rhesus macaque θ-Defensin
Disulfide pattern CysI–CysVI, CysII–CysV, CysIII–CysIV
|Product Number||Product Name|
|4025473||Defensin HNP-1 (human)|
|4025474||Defensin HNP-2 (human)|
|4025495||Defensin HNP-3 (human)|
|4102158||Defensin 5 (human)|
|4038285||rec β-Defensin 1 (human)|
|4038287||rec β-Defensin 2 (human)|
|4034693||β-Defensin 2 (human)|
|Product Name||Companies Involved||Highest Phase||Condition/Application|
|Brilacidin||Innovation Pharmaceuticals; Alfasigma||II||Skin and Skin Structure Infections (SSSI) Caused by Bacteria; Oral Mucositis; Proctitis|
|Human α-defensin 5||Defensin Therapeutics ApS||Preclinical||Asthma; Inflammatory Bowel Disease; Metabolic Syndrome|
|Human β-defensin 2||Defensin Therapeutics ApS; Dr. Falk Pharma||Preclinical||Asthma; Metabolic Syndrome; Crohn's Disease|
What is your official job title at Bachem?
SAP Specialist Supply Chain Management.
How long have you been with Bachem? Where did you work before Bachem?
I have been with Bachem for four years and I worked for several pharmaceutical companies before Bachem.
Briefly, what do you do at Bachem?
I am responsible for two SAP modules to handle all the incidents and change requests related to these modules.
What is your academic background/degrees or training?
I have a Bachelor degree in public relations and English. I also have a Project Management Professional (PMP) certificate and SAP Material Management (MM) certificate.
What do you like to do outside of work?
I am fond of skiing, swimming, and hiking. I love to spend time in nature.
What makes a perfect day for you?
A day that starts with a smile.
What do you like most about your job?
Together with experts from each business area, finding the best solution in the SAP system to meet the business requirements
Have you had any particular expectation when you came to Bachem and have these been fulfilled?
I came to Bachem with a lot of years working in big companies, feeling that I was just one of the thousands of employees. Here at Bachem, it is more like a family and every family member’s contribution matters.
What do you do for fun?
Enjoy a wonderful evening with my girlfriends and skiing with my kids.
Would you like to communicate any key message to the reader?
I am very proud of being a member of the Bachem family.
Thank you very much Ni.
Interesting news about peptides in basic research and pharmaceutical development:
Foot-and-mouth-disease virus could help target the deadliest cancer-Queen Mary University of London
Alzheimer’s disease protein aggregation prevented by cell-penetrating peptides-Genetic Engineering & Biotechnology News
D6PV peptide lowers triglycerides in mouse bloodstream, shows study-Drug Target Review