Webinar Replays can be found hereabout the Event Peptide and oligonucleotide drugs are versatile therapeutics with a growing range of applications and many similarities in terms and of manufacturing and regulation. New formulations often increase the complexity of the products and demand innovative solutions. Partnering with an experienced CDMO can support drug developers’ manufacturing needs […]
Register nowabout the Event Peptide and oligonucleotide drugs are versatile therapeutics with a growing range of applications and many similarities in terms and of manufacturing and regulation. New formulations often […]
Webinar Replays can be found here about the Event The use of enzymes is a key component in making manufacturing routes of active pharmaceutical ingredients (APIs) more sustainable and environmentally friendly. Learn in this webinar how enzymes - used for chemo-enzymatic peptide synthesis produced by EnzyTag - enable greener peptide syntheses and what questions appear […]
Webinar Replays can be found hereabout the Event In collaboration with Novo Nordisk we identified more environmentally benign and less hazardous alternatives to N,N-dimethylformamide (DMF) in solid-phase peptide synthesis (SPPS): mixtures of two green solvents (binary solvents). Learn in this webinar how the polarity and viscosity profiles of binary solvents can be used to predict […]
Webinar Replays can be found hereabout the Event Regulatory agencies worldwide have requested drug authorization holders to evaluate drug product and drug substances processes for the possibility of introducing nitrosamine impurities with a systematic risk assessment. Bachem assesses both our solid phase peptide synthesis (SPPS) and liquid phase peptide synthesis (LPPS) processes regarding their potential […]
about the Event Developing and producing peptide-based drugs requires toxic reagents and enormous amounts of organic solvents. Catch-and-release methods, like Belyntic’s Peptide Easy Clean (PEC) technology, can significantly improve the ecological footprint of the entire operation. From high-throughput to large-scale projects, PEC combines green solid-phase peptide synthesis (SPPS) with a precipitation-free workup and a low […]
Webinar Replay about the Event Ensuring responsible sourcing of our goods and services is paramount for continuous improvement of our performance as outlined in our Corporate Social Responsibility framework. Learn more about our initiatives directed at making our supply chain more sustainable and resilient. We will talk about our supplier sustainability assessments and responsible sourcing […]
Webinar Replay about the Event In 2021, Bachem acquired the first two process-scale Multicolumn Counter-current Solvent Gradient Purification (MCSGP) systems for the purification of peptides and oligonucleotides. The systems are qualified for GMP use for which first purifications at scale were successfully performed. In this webinar, our efforts to establish large-scale MCSGP will be presented, […]
Webinar Replay about the Event At Bachem, we are constantly striving to improve our industry standards by developing innovative and efficient large-scale manufacturing processes for active pharmaceutical ingredients (APIs). Thereby, our operations entered the Industry 4.0 era and started their business transformation towards a smart factory. Watching this webinar, you will learn more about our […]
about the Event In this webinar we will present direct, robust and easy-to-use techniques to fully characterize the nucleotide sequence of highly modified single-stranded RNAs by top down tandem MS. This will include a case study for a N-acetylgalactosamine modified RNA sense strand. The approach can be applied on a single strand level, as well […]
Cysteine (Cys) is a key amino acid in many therapeutic peptides. Cys amino acid residues, involved in the formation of two important peptide bonds, the amide and disulfide bonds, and in thioether formation for peptide cyclization, are also very sensitive to the occurrence of side reactions during solid-phase peptide synthesis. Epimerization is an often-underestimated problem […]