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Source: Bachem Product Monograph – Diabetes Peptides, August 2019
Glucagon is a 29 amino acid peptide and its sequence is known to be highly conserved across mammalian species. Structurally, glucagon is related to the secretin family of peptide hormones. The glucagon sequence is synthesized as proglucagon and proteolytically processed into glucagon by prohormone convertase 2 (PC2) within the α cells of the pancreatic islets. Proglucagon is also expressed in the intestinal tract. In the intestinal enteroendocrine cells (L-cells), prohormone convertase 1/3 (PC1/3) is greater than PC2 action so the proglucagon sequence is cleaved to yield GLP-1, GLP-2, oxyntomodulin, glicentin and IP2 (Figure 2). There is evidence that PC1/3 is also expressed in the α cells of the pancreatic islets but at lower levels than PC2 suggesting that there is some pancreatic islet production of GLP-1 (2).
Figure 2 Processing of Proglucagon in the Pancreas and the Intestine
(GRPP: Glicentin-related Pancreatic Peptide, IP: Intervening Peptide; GLP: Glucagon-like Peptide)
|Product Name||Pipeline Indication(s)||Highest Development Stage||Companies|
|Gvoke HypoPen||Hypoglycemia; Hypoglycemia-associated autonomic failure; Hyperinsulinemia||Pre-registration||Xeris Pharmaceuticals|
|Dasiglucagon||Hyperinsulinemia; Hypoglycemia; Type 1 Diabetes||Phase III||Zealand Pharma AS|
|Biochaperone Glucagon||Hypoglycemia||Phase I||Adocia SAS|
What is your official job title at Bachem?
I am a part-time working student in the marketing team. Currently, I am also in the Business Development & Sales team equally as a part-time worker.
How long have you been with Bachem? Where did you work before Bachem?
I am here at Bachem since April 2019. Before that, I worked for a year in the finance department of the Canton of Basel-Stadt as Junior Project Management Officer.
Briefly, what do you do at Bachem?
In the Global Marketing Team, I am responsible for two internal team projects. At Business Development & Sales, I am temporary supporting a big project.
What is your academic background/degrees or training?
Rinson: I am currently completing my Bachelor of Science in Business IT at the FHNW as a part-time student. Before that, I completed my apprenticeship as a computer scientist in systems engineering and then absolved my technical vocational Matura.
What do you like to do outside of work?
In my free time, I like to spend time with my friends and family. My hobbies are to play football and do some workouts at the gym.
What makes a perfect day for you?
If I can go to bed in the evening with the conscience that I have put meaningful work, help or activity on the day.
Thank you very much Rinson.
Interesting news about peptides in basic research and pharmaceutical development:
Anti-cancer immune cells protect against MS in mice-FierceBiotech
New mechanism that could counteract obesity-Science Daily
Lilly’s new diabetes treatment now available in USA-ThePharmaLetter