Icatibant Acetate

4043056

Bachem Regulatory Documentation

DMF

Synonyms

(D-Arg0,Hyp3,Thi5,D-Tic7,Oic8)-Bradykinin; HOE140

Sequence

H-D-Arg-Arg-Pro-Hyp-Gly-Thi-Ser-D-Tic-Oic-Arg-OH
acetate salt

Fields of Application

Hereditary angioedema
ACE inhibitor-induced angioedema (off-label use)

Active Substance

Icatibant Acetate is a selective competitive antagonist for the bradykinin B2 receptor. It is indicated for the treatment of acute attacks of hereditary angioedema (HAE). HAE is a rare disorder resulting in periodic attacks of acute edema. It is characterized by a deficiency of functional C1 esterase inhibitor that leads to the overproduction of bradykinin, which triggers vasodilation, vascular permeability, and edema. Icatibant Acetate inhibits bradykinin from binding to the B2 receptor and thereby treats the clinical symptoms of an acute, episodic attack of HAE.

Molecular Information

Molecular Formula

C59H89N19O13S

Relative Molecular Mass

1304.54g/mol

CAS-Number

130308-48-4 (net), 138614-30-9 (acetate)

Long-term Storage

5 ± 3°C