16960-16-0 (net), 60189-34-6 (acetate)

H-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-OH acetate salt

What is tetracosactide/cosyntropin acetate?​

Tetracosactide (also known as cosyntropin) acetate is a synthetic polypeptide that corresponds to the first 24 amino acids of the naturally occurring adrenocorticotropic hormone (ACTH). This synthetic analogue mimics the biological activity of natural ACTH, primarily stimulating the adrenal cortex to produce and release cortisol and other corticosteroids. 

As a highly specific and potent ACTH analogue, tetracosactide acetate serves as a valuable tool in endocrine medicine for evaluating adrenal insufficiency and treating certain autoimmune conditions.

Tetracosactide acetate mechanism of action

Tetracosactide acetate functions by binding to melanocortin-2 receptors (MC2R) on the surface of adrenocortical cells in the adrenal glands. This binding initiates a signalling cascade that activates adenylate cyclase, leading to increased intracellular cyclic AMP(cAMP) levels. The elevated cAMP triggers protein kinase A activation, which ultimately results in the synthesis and release of corticosteroids, primarily cortisol. Additionally, it stimulates the production of other adrenal hormones including aldosterone and androgens. 

The drug’s mechanism closely mirrors that of natural ACTH, making it particularly effective for both diagnostic testing of adrenal function and therapeutic applications.

What is tetracosactide used for?

Tetracosactide serves both diagnostic and therapeutic purposes in clinical medicine. Diagnostically, it is primarily used in the ACTH stimulation test (short synacthen test) to assess adrenal function and diagnose conditions such as Addison’s disease, congenital adrenal hyperplasia, and secondary adrenal insufficiency. The test evaluates the adrenal glands’ ability to respond to ACTH by measuring cortisol levels before and after administration. 

Therapeutically, tetracosactide can be used to treat various medical conditions, including certain types of epilepsy, particularly West syndrome (infantile spasms) and Lennox-Gastaut syndrome. It is also used in managing some autoimmune and inflammatory conditions, where its ability to stimulate endogenous cortisol production can help reduce inflammation and modulate immune responses.

The drug has also shown to be very effective in specific cases of multiple sclerosis relapses, certain rheumatic conditions, and various inflammatory bowel diseases where conventional steroid therapy is not always suitable or effective.

In veterinary medicine, tetracosactide (cosyntropin) is used as a diagnostic for detecting adrenal disorders in dogs, horses, and cats.

Why choose Bachem as your tetracosactide acetate manufacturer?

Choose Bachem as your tetracosactide acetate manufacturer and tap into five decades of peptide synthesis expertise. We’ve perfected the art of producing this complex 24-amino acid peptide, ensuring you receive products of exceptional quality every time. Our manufacturing process has been refined through years of hands-on experience, resulting in outstanding purity profiles and consistent yields.

We understand the critical importance of tetracosactide acetate in diagnostic testing and therapeutic applications. That’s why we’ve invested in dedicated production suites and specialized analytical capabilities to meet your exact requirements. 

Working with us means accessing comprehensive regulatory support, including current DMFs and CEPs, alongside personalised project management. Whether you need small quantities for research or large-scale commercial supply, we adapt to your needs while maintaining the highest quality standards.

How do we guarantee the highest quality products?

At Bachem, we uphold the highest quality standards throughout the entire API manufacturing process. Our commitment begins with stringent raw material selection, ensuring that only top-quality ingredients enter our production pipeline. From there, we apply specialised purification techniques and process controls tailored specifically for APIs, focusing on precision and consistency.

Operating under current Good Manufacturing Practice (cGMP) guidelines, our global manufacturing network is regularly audited by regulatory bodies. We utilize cutting-edge analytical methods to thoroughly characterize each product, with impurity profiles meticulously monitored. Every batch undergoes rigorous testing and we provide detailed certificates of analysis for full transparency.

Our facilities undergo regular quality audits, not only by regulatory bodies but also by our clients, underscoring our dedication to compliance and transparency. We take pride in our experienced teams, who continually expand their knowledge and skills to stay ahead of industry advancements. This commitment allows us to deliver APIs that meet and exceed client expectations, making us a trusted partner in the pharmaceutical sector.

Related generic APIs and services

Trust our market-leading expertise. We’ve successfully commercialised more than 25 of the world’s approved peptide APIs in new chemical entities (NCEs) and generics. With decades of proven experience and comprehensive development capabilities, we are uniquely positioned to transform your innovations into global commercial success.

Tetracosactide (cosyntropin) is a synthetic peptide corresponding to the N-terminal 24 amino acids of the naturally occurring hormone ACTH (adrenocorticotropic hormone). Tetracosactide stimulates the adrenal cortex to produce corticosteroids, mineralocorticoids, and, to a lesser extent, androgens.
In veterinary medicine, tetracosactide (cosyntropin) is used as a diagnostic for detecting adrenal disorders in dogs, horses, and cats.

Molecular Formula

C₁₃₆H₂₁₀N₄₀O₃₁S

Relative Molecular Mass

2933.48 g/mol

Long-term Storage

-20 ± 5°C

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