Tetracosactide
H-1150-GMP, 4042686
Bachem Regulatory Documentation
DMF
Synonyms
Cosyntropin; Tetracosactrin; α1-24-Corticotropin; ACTH (1-24)
Sequence
H-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-OH acetate salt
Fields of Application
Investigation of adrenocortical insufficiency
Neurological diseases
Rheumatic diseases
Skin diseases
Diseases of the intestinal tract
Oncology
Neurological diseases
Rheumatic diseases
Skin diseases
Diseases of the intestinal tract
Oncology
Active Substance
Tetracosactide (cosyntropin) is a synthetic peptide corresponding to the N-terminal 24 amino acids of the naturally occurring hormone ACTH (adrenocorticotropic hormone). Tetracosactide stimulates the adrenal cortex to produce corticosteroids, mineralocorticoids, and, to a lesser extent, androgens.
In veterinary medicine, tetracosactide (cosyntropin) is used as a diagnostic for detecting adrenal disorders in dogs, horses, and cats.
Molecular Information
Molecular Formula
C136H210N40O31S
Relative Molecular Mass
2933.48 g/mol
CAS-Number
16960-16-0 (net), 60189-34-6 (acetate)
Long-term Storage
-20 ± 5°C