Tetracosactide

H-1150-GMP, 4042686

Bachem Regulatory Documentation

DMF

Synonyms

Cosyntropin; Tetracosactrin; α1-24-Corticotropin; ACTH (1-24)

Sequence

H-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-OH acetate salt

Fields of Application

Investigation of adrenocortical insufficiency
Neurological diseases
Rheumatic diseases
Skin diseases
Diseases of the intestinal tract
Oncology

Active Substance

Tetracosactide (cosyntropin) is a synthetic peptide corresponding to the N-terminal 24 amino acids of the naturally occurring hormone ACTH (adrenocorticotropic hormone). Tetracosactide stimulates the adrenal cortex to produce corticosteroids, mineralocorticoids, and, to a lesser extent, androgens.
In veterinary medicine, tetracosactide (cosyntropin) is used as a diagnostic for detecting adrenal disorders in dogs, horses, and cats.

Molecular Information

Molecular Formula

C136H210N40O31S

Relative Molecular Mass

2933.48 g/mol

CAS-Number

16960-16-0 (net), 60189-34-6 (acetate)

Long-term Storage

-20 ± 5°C