LEUPROLIDE ACETATE

Leuprolide Acetate

H-4060-GMP, 4008634

Bachem Regulatory Documentation

CEP, DMF

Synonyms

Leuprorelin; (Des-Gly¹⁰,D-Leu⁶,Pro-NHEt⁹)-LHRH

Sequence

Pyr-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt acetate salt

Fields of Application

Advanced hormone-dependent prostate cancer
Advanced hormone-dependent breast cancer
Endometriosis
Uterine myoma
Central precocious puberty

Active Substance

Leuprolide Acetate is a potent LHRH (GnRH) agonist. After a transient increase, continuous administration of leuprolide results in downregulation of LH and FSH levels followed by a suppression of ovarian and testicular steroid biosynthesis. Studies with female Alzheimer patients indicate that application of leuprolide acetate in combination with an acetylcholinesterase inhibitor stabilizes the cognitive functions in mild-to-moderate cases.

Molecular Formula
C₅₉H₈₄N₁₆O₁₂

Relative Molecular Mass
1209.5 (net)

CAS-Number
53714-56-0 (net), 74381-53-6 (acetate)

Long-term Storage
-20 ± 5°C

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Also available

Related Research Grade Peptides

4033014	(Des-Gly¹⁰,D-Leu⁶,Pro-NHEt⁹)-LHRH (Leuprolide; Leuprorelin)
4048762	(Des-Gly¹⁰,D-Leu⁶,[¹³C₆]Leu⁷,Pro-NHEt⁹)-LHRH (([¹³C₆]Leu⁷)-Leuprolide; ([¹³C₆]Leu⁷)-Leuprorelin)
4065127	(Des-Gly¹⁰,Des-Ser⁴,D-Leu⁶,Pro-NHEt⁹)-LHRH ((Des-Ser⁴)-Leuprolide; (Des-Ser⁴)-Leuprorelin)
4028311	(Des-Gly¹⁰,D-His²,D-Leu⁶,Pro-NHEt⁹)-LHRH ((D-His²)-Leuprolide; (D-His²)-Leuprorelin) Impurity Bof the Leuprorelin Ph. Eur. monograph
4048380	(Des-Gly¹⁰,D-His²,D-Ser⁴,D-Leu⁶,Pro-NHEt⁹)-LHRH ((D-His²,D-Ser⁴)-Leuprolide; (D-His²,D-Ser⁴)-Leuprorelin) Impurity F of the Leuprorelin Ph. Eur. monograph
4028310	(Des-Gly¹⁰,D-Leu⁶,D-Leu⁷,Pro-NHEt⁹)-LHRH ((D-Leu⁷)-Leuprolide; (D-Leu⁷)-Leuprorelin) Impurity Hof the Leuprorelin Ph. Eur. monograph

4065128	(Des-Gly¹⁰,D-Leu⁶,Orn⁸,Pro-NHEt⁹)-LHRH ((Orn⁸)-Leuprolide; (Orn⁸)-Leuprorelin)
4033802	(Des-Gly¹⁰,Leu⁶,Pro-NHEt⁹)-LHRH ((Leu⁶)-Leuprolide; (Leu⁶)-Leuprorelin) Impurity C of the Leuprorelin Ph. Eur. monograph
4046113	(Des-Gly¹⁰,D-Pyr¹,D-Leu⁶,Pro-NHEt⁹)-LHRH ((D-Pyr¹)-Leuprolide; (D-Pyr¹)-Leuprorelin) Impurity I of the Leuprorelin Ph. Eur. monograph
4033803	(Des-Gly¹⁰,D-Ser⁴,D-Leu⁶,Pro-NHEt⁹)-LHRH ((D-Ser⁴)-Leuprolide; (D-Ser⁴)-Leuprorelin) Impurity A of the Leuprorelin Ph. Eur. monograph
4034724	(Des-Gly¹⁰,Ser(Ac)⁴,D-Leu⁶,Pro-NHEt⁹)-LHRH ((Ser(Ac)⁴)-Leuprolide; (Ser(Ac)⁴)-Leuprorelin) Impurity D of the Leuprorelin Ph. Eur. monograph

4058815	(Des-Gly¹⁰,D-Trp³,D-Leu⁶,Pro-NHEt⁹)-LHRH ((D-Trp³)-Leuprolide; (D-Trp³)-Leuprorelin) Impurity E of the Leuprorelin Ph. Eur. monograph
4028312	(Des-Gly¹⁰,D-Tyr⁵,D-Leu⁶,Pro-NHEt⁹)-LHRH ((D-Tyr⁵)-Leuprolide; (D-Tyr⁵)-Leuprorelin) Impurity G of the Leuprorelin Ph. Eur. monograph
4037360	(D-Leu⁶)-LHRH (1-8) (free acid) ((Des-Pro-NHEt⁹)-Leuprolide; (Des-Pro-NHEt⁹)-Leuprorelin)
4027694	(D-Leu⁶,Pro-NHEt⁹)-LHRH (4-9) (Leuprolide (4-9), Leuprorelin (4-9))

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